Articles NSK en rapport avec nonmem

SIMON N, MOIRAND R, DEMATTEIS M, BORDET R, DEPLANQUE D, ROLLAND B. Full-Profile Pharmacokinetic Study of High Dose Baclofen in Subjects With Alcohol Use Disorder. Front Psychiatry. 2018 Aug 23;9:385. doi: 10.3389/fpsyt.2018.00385.

IMBERT B, ALVAREZ JC, SIMON N. Anticraving Effect of Baclofen in Alcohol-Dependent Patients. Alcohol Clin Exp Res. 2015 Jul 24. doi: 10.1111/acer.12823. [Epub ahead of print]

SIMON N, FINZI J, CAYLA G, MONTALESCOT G, COLLET JP, HULOT JS. Omeprazole, pantoprazole, and CYP2C19 effects on clopidogrel pharmacokinetic-pharmacodynamic relationships in stable coronary artery disease patients. Eur J Clin Pharmacol. 2015 Jun 14. [Epub ahead of print]

JESKE W., HOPPENSTEADT D., FAREED J., WALENGA J., CUNANAN J., BAKHOS M., SIMON N., ESCALANTE V.. Differences in pharmacokinetic behaviour of branded enoxaparin and a US generic version in a non-human primate model Generics and Biosimilars Initiative Journal (GaBI Journal). 2015;4(2): Epub ahead of print

SIMON N, AZORIN JM. [Rational estimation of drug dosage through pharmacometric modeling: The case of a long-acting depot antipsychotic]. [Article in French] Encephale. 2015 Apr; 41(2):159-67. doi: 10.1016/j.encep.2015.02.001. Epub 2015 Mar 9.

SCALA C, MARSOT A, LIMOGES MJ, LOCATELLI Y, SIMON N, ALVAREZ JC. Population pharmacokinetics of methadone hydrochloride after a single intramuscular administration in adult Japanse sika deer (Cervus nippon nippon). Vet Anaesth Analg. 2014 JUN 25. DOI: 10.1111/VAA.12186. [EPUB AHEAD OF PRINT]

MARSOT A, IMBERT B, ALVAREZ JC, GRASSIN-DELYLE S, JAQUET I, LANCON C, SIMON N. High variability in the exposure of baclofen in alcohol dependent patients. Alcohol Clin Exp Res. 2014; 38: 316-21. [Epub ahead of print]

MARSOT A, GOIRAND F, MILÉSI N, DUMAS M, BOULAMERY A, SIMON N. Interaction of thiopental with esomeprazole in critically ill patients. Eur J Clin Pharmacol 2013; 69: 1667-72.. [Epub ahead of print]

MARSOT A, BREVAUT-MALATY V, VIALET R, BOULAMERY A, BRUGUEROLLE B, SIMON N. Pharmacokinetics and absolute bioavailability of phenobarbital in neonates and young infants, a population pharmacokinetic modelling approach. Fundam Clin Pharmacol. 2013 Jun 14. doi: 10.1111/fcp.12042. [Epub ahead of print]

BOULAMERY A, MARSOT A, BRUGUEROLLE B, SIMON N.Population pharmacokinetics of ertapenem in juvenile and old rats. Fundam Clin Pharmacol. 2013 May 5. doi: 10.1111/fcp.12017. [Epub ahead of print]

MARSOT A, BOULAMERY A, BRUGUEROLLE B, SIMON N. Population pharmacokinetic analysis during the first two years of life: an overview. Clin Pharmacokinet 2012; 51(12):787-98.

SIMON N, MARSOT A, VILLARD E, CHOQUET S, KHE HX, ZAHR N, LECHAT P, LEBLOND V, HULOT JS. Impact of ABCC2 polymorphisms on high-dose methotrexate pharmacokinetics in patients with lymphoid malignancy. Pharmacogenomics J. 2012 Oct 16. doi: 10.1038/tpj.2012.37. [Epub ahead of print]

MARSOT A, VIALET R., BOULAMERY A, BRUGUEROLLE B, SIMON N. Vancomycine: Predictive performance of a population pharmacokinetic model and optimal dose in neonates and young infants. Clinical pharmacology in drug development. 2012 in press.

PÉRUS O, MARSOT A, RAMAIN E, DAHMAN M, PACI A, RAUCOULES-AIMÉ M, SIMON N. Performance of alfentanil target-controlled infusion in normal and morbidly obese female patients. Br J Anaesth. 2012; 109(4):551-60

MARSOT A, BOULAMERY A, BRUGUEROLLE B, SIMON N. Vancomycin: a review of population pharmacokinetic analyses. Clin Pharmacokinet. 2012;51:1-13.

GUILHAUMOU R, SOLAS C, BOURGAREL-REY V, QUARANTA S, ROME A, SIMON N, LACARELLE B, ANDRE N. Impact of plasma and intracellular exposure and CYP3A4, CYP3A5, and ABCB1 genetic polymorphisms on vincristine-induced neurotoxicity. Cancer Chemother Pharmacol. 2011; 68:1191-8.

GAROT D, RESPAUD R, LANOTTE P, SIMON N, MERCIER E, EHRMANN S, PERROTIN D, DEQUIN P, LE GUELLEC C. Population pharmacokinetics of ceftriaxone in critically ill septic patients: a reappraisal. Br J Clin Pharmacol. 2011; 72:758-67

BOYADJIEV I, BOULAMERY A, SIMON N, MARTIN C, BRUGUEROLLE B, LEONE M. Penetration of ertapenem into muscle measured by in vivo microdialysis in mechanically ventilated patients. Antimicrob Agents Chemother. 2011; 55: 3573-5

C. OUDIN, R. VIALET, A. BOULAMERY, C. MARTIN, N. SIMON. Vancomycin prescription in neonates and young infants: toward a simplified dosage. Arch Dis Child Fetal Neonatal Ed. 2011; 96: F365-70 [Epub ahead of print]

GUILHAUMOU, N. SIMON, S. QUARANTA, A. VERSCHUUR, B. LACARELLE, N. ANDRE, C. SOLAS. Population pharmacokinetics and pharmacogenetics of vincristine in paediatric. patients treated for solid tumour diseases. Cancer Chemother Pharmacol. 2010 Dec 14. [Epub ahead of print]

N. SIMON, F. CASTINETTI, F. OULIAC, N. LESAVRE, T. BRUE, C. OLIVIER. Pharmacokinetic évidence for suboptimal treatment of adrenal insufficiency with currently available hydrocortisone tablets. Clinical Pharmacokinet. 2010 ; 49: 455-463.

B. GUILLET, N. SIMON, R. PURGUS, C. BOTTA, Y. BERLAND, P.J. PISANO. Population pharmacokinetic analysis of mycophenolic acid in adult kidney transplant patients with chronic graft dysfunction. Therapeutic Drug Monitoring 2010 ; 32: 427-32

H. ABOUHAMMOUD, N SIMON, S URIEN, B RIOU, P LECHAT, F AUBRUN. Intravenous morphine titration in immediate postoperative pain management: population kinetic-pharmacodynamic and logistic regression analysis. Pain. 2009 ; 144: 139-46.

C. SOLAS, MC GAGNIEU, I RAVAUX, MP DROGOUL, A LAFEUILLADE, S MOKHTARI, B LACARELLE, N. SIMON. Population pharmacokinetics of atazanavir in HIV-infected patients. Ther Drug Monit 2008; 30: 670-3

N. SEMMAR, S. URIEN, B. BRUGUEROLLE, N. SIMON. Independent-model diagnostics for a priori identification and interpretation of outliers from a full pharmacokinetic database: correspondence analysis, Mahalanobis distance and Andrews curves. J Pharmacokinet Pharmacodyn. 2008 ; 35: 159-83

P. BRUNET, N. SIMON, A. OPRIS, V. FAURE, A.-M. LOREC-PENET, H. PORTUGAL (3), B. DUSSOL, Y. BERLAND. Pharmacodynamics of unfractionated heparin during and after hemodialysis session. Am J Kidney Dis. 2008; 51: 789-95

A. BOULAMERY, G. KADRA, N. SIMON, T. BESNARD, B. BRUGUEROLLE, A Chronopharmacokinetics of imipenem in the rat. Chronobiol Int. 2007; 24: 961-8.

C. SOLAS, N. SIMON, M.-P. DROGOUL, S. QUARANTA, V. FRIXON-MARIN, V. BOURGAREL-REY, C. BRUNET, J.-A. GASTAUT, A. DURAND, B. LACARELLE, I. POIZOT-MARTIN. Minimal effect of MDR1 and CYP3A5 genetic polymorphisms on the pharmacokinetics of indinavir in HIV-infected patients. Br J Clin Pharmacol 2007; 64: 353-62.

L. BECQUEMONT, H. GLAESER, S. DRESCHER, M. HITZL, N. SIMON, T. MURDTER, G. HEINKELE, U. HOFMANN, C. SCHAEFER, O. BURK, C. VERSTUYFT, M. EICHELBAUM, M. FROMM. Effects of Ursodeoxycholic acid on P-glycoprotein and CYP3A4-dependent Pharmacokinetics in Man. Clin Pharmacol Ther.2006; 79: 449-460

N. SIMON, B. DUSSOL, E. SAMPOL, R. PURGUS, P. BRUNET, B. LACARELLE, Y. BERLAND, B. BRUGUEROLLE, S. URIEN. Population pharmacokinetics of ceftriaxone and pharmacodynamic considerations in haemodialyzed patients. Clinical Pharmacokinet. 2006; 45: 493-501

N. SEMMAR, N. SIMON. Review in pharmacokinetic models on corticoids. Mini Rev Med Chem 2006; 6: 417-428

N. SEMMAR, B. BRUGUEROLLE, N. SIMON. Cluster analysis: an alternative method for covariate selection in population pharmacokinetic modeling. J Pharmacokinet Phar.2005; 32: 333-358

T. TRENQUE, N. SIMON, I. VILLENA, C. CHEMLA, C. QUEREUX, B. LEROUX, R. JAUSSAUD, G. REMY, D. DUPOUY, H. MILLART, J.-M. PINON, S. URIEN. Population Pharmacokinetics of pyrethamine and sulfadoxine in children with congenital toxoplasmosis. Br J Clin Pharmacol 2004; 57: 735-741.

R. DEPORTE-FETY, N. SIMON, P. FUMOLEAU, M. CAMPONE, P. KERBRAT, J. BONNETERRE, P. FARGEOT, S URIEN Population pharmacokinetics of short intravenous vinorelbine infusions in patients with metastatic breast cancer. Cancer Chemother Pharmacol. 2004; 53: 233-238.

N. SIMON, E. SAMPOL, J. ALBANESE, C. MARTIN, P. ARVIS, S. URIEN, B. LACARELLE, B. BRUGUEROLLE. Population pharmacokinetics of moxifloxacin in plasma and bronchial secretions in patients with severe bronchopneumonia. Clin Pharmacol Ther. 2003; 74: 353-363.

B. GUILLET, N. SIMON, J SAMPOL, A-M LOREC-PENET, H. PORTUGAL, Y. BERLAND, B. DUSSOL, P. BRUNET. Pharmacokinetics of the low molecular weight heparin enoxaparin during 48 hours hemodialysis anticoagulation. Nephrol Dial Transplant 2003; 18: 2348-2353

G. SLEPCHENKO, N. SIMON, B. GOUBAUX, J.-C. LEVRON, J-P LE MOING, M. RAUCOULES-AIME. Performance of Sufentanil Target Controlled infusion in Obese Patients. Anesthesiology 2003; 98: 65-73

H. RUSSO, N. SIMON, MP. DUBOIN, S. URIEN. Population pharmacokinetics of high-dose thiopenthal in patients with cerebral injuries. Clin Pharmacol Ther 1997; 62: 15-20.